Dextran sulfate sodium (DSS) for colitis
CAS no. 9011-18-1
The DSS is supplied as the sodium salt and is stabilised by a small addition of phosphate salts. DSS is stable indefinitely when stored in well sealed containers at room temperature. A certificate of analysis is supplied with each batch. The molecular weight range, sulphur content, moisture etc are carefully controlled.
Dextran sulphate sodium (DSS) with a mol. wt. of approx. 40000 when administered orally in the drinking water has been found to induce colitis in experimental animals. Concentrations from 2 to 5% have been used and symptoms develop within one week. The recommended concentrations of DSS for mice are 2.5-3.5% and this will depend, eg. on the strain, age and sex of the animals. For rats somewhat higher concentrations may be required 3.5-5%. It will also depend on whether your study requires a milder onset of colitis or a more aggresive response.
Reference: A-C. Bylund-Fellenius, E.Landström, L-G.Axelsson and T.Midtvedt,Microb.Ecol.,1994:7;207.
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