Phenyl Dextran

It is well established that most proteins and indeed other biopolymers and carbohydrates possess hydrophobic regions and that these regions are important features in interactions with other surfaces.

This phenomenon is made use of in chromatographic separations and gels have been designed to take advantage of this property.

These hydrophobic interactions are stronger in more concentrated salt solutions and weaker as the solution is diluted. In aqueous systems, solvation of these areas is energetically unfavorable and hydrophobic cavities may be formed in the aqueous phase. 

We now introduce phenyl dextrans to our range of products. Phenyl dextran is also known as Phenoxy dextran, DexP, phenoxy-derivatized dextran or 1-Phenoxy-2-hydroxypropyl dextran. Phenyl dextrans may be used in the preparation of hydrophobic gels and hydrophobic coatings. First off the starting line is phenyl dextran 40, made by derivatizing dextran 40 with phenyl glycidyl substituents. The phenyl content is determined by absorbance (as phenyl glycidyl content w/w). This level of substitution corresponds to one phenyl residue for every five glucose units in the dextran chain. The product is water soluble at low concentrations, but requires prolonged stirring. At higher concentrations the phenyl dextran will aggregate giving the solution an opaque apperance. The range of products will be extended to provide different molecular weights and also different degrees of substitution.