DEAE-dextrans
CAS No. 9015-73-0
DEAE-substituents have been introduced into a range of dextran fractions. The chemical reaction introduces two types of substituents.
The predominant substituent is the single tertiary group (blue) but this reacts further in some cases to yield a "tandem" group (red) containing a quarternary amine as well as the tertiary amine. A titration curve reveals the proportions (Fig.2).
DEAE-dextrans are supplied as a white hygroscopic powder which are readily soluble in water and salt solutions. The powder is stable at room temperature for more than three years providing it is stored in well-sealed containers in the dark.
DEAE-dextrans are used in various areas:
- As adjuvant for vaccines
- In transfection techniques and viral infectivity
- For stabilisation of proteins (enzymes)
If you need larger quantities please contact us for a bulk quotation.
References
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- Li, B. et al. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials 194, 139–150 (2019).
- Antunes, J. C. et al. Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells. Molecular Therapy - Nucleic Acids 17, 210–222 (2019).
- Matuszak, J. et al. Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions. Nanotoxicology 12, 957–974 (2018).
- Matuszak, J. et al. Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing. Nanomedicine 11, 597–616 (2016).
- Adal, Y., Pratt, L. & Comper, W. D. Transglomerular Transport of DEAE Dextran in the Isolated Perfused Kidney. Microcirculation 1, 169–174 (1994).
