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DEAE-dextrans

CAS No. 9015-73-0

DEAE-substituents have been introduced into a range of dextran fractions. The chemical reaction introduces two types of substituents.

The predominant substituent is the single tertiary group (blue) but this reacts further in some cases to yield a "tandem" group (red) containing a quarternary amine as well as the tertiary amine. A titration curve reveals the proportions (Fig.2). 

DEAE-dextrans are supplied as a white hygroscopic powder which are readily soluble in water and salt solutions. The powder is stable at room temperature for more than three years providing it is stored in well-sealed containers in the dark.

DEAE-dextrans are used in various areas: 

  • As adjuvant for vaccines 
  • In transfection techniques and viral infectivity 
  • For stabilisation of proteins (enzymes)

If you need larger quantities please contact us for a bulk quotation. 

References

Have you cited this product in a publication? Let us know so we can reference it.

  1. Li, B. et al. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials 194, 139–150 (2019).
  2. Antunes, J. C. et al. Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells. Molecular Therapy - Nucleic Acids 17, 210–222 (2019).
  3. Matuszak, J. et al. Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions. Nanotoxicology 12, 957–974 (2018).
  4. Matuszak, J. et al. Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing. Nanomedicine 11, 597–616 (2016).
  5. Adal, Y., Pratt, L. & Comper, W. D. Transglomerular Transport of DEAE Dextran in the Isolated Perfused Kidney. Microcirculation 1, 169–174 (1994).

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DEAE-dextran 4 (DD4)

DEAE-dextran 4 (DD4)

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DEAE-dextran 10 (DD10)

DEAE-dextran 10 (DD10)

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DEAE-dextran 20 (DD20)

DEAE-dextran 20 (DD20)

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DEAE-dextran 70 (DD70)

DEAE-dextran 70 (DD70)

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DEAE-dextran 150 (DD150)

DEAE-dextran 150 (DD150)

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DEAE-dextran 500 (DD500)

DEAE-dextran 500 (DD500)

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995 SEK
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DEAE-dextran 2000 (DD2000)

DEAE-dextran 2000 (DD2000)

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995 SEK
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