Need help?

Check our ORDER INFORMATION or FAQ

FITC dextran

FITC-dextrans have now been used for 25 years for studying microcirculation or membrane permeability.

FITC dextrans are prepared from special dextran fractions by coupling to fluoresceinyl isothiocyanate (5-isomer). The number of FITC substituents ranges from 0.002-0.008 per glucose unit. At these low degrees of substitution, the charge contribution from the carboxyl group on the fluoresceinyl moiety is negligible. All batches are checked for molecular weight, loss on drying and free FITC.

If you need larger quantities please contact us for a bulk quotation.

For a presentation of intravital studies using fluorescent dextrans pdfintravital_studies.pdf.

References

Have you cited this product in a publication? Let us know so we can reference it.

2019

    1. Torge, A., Pavone, G., Jurisic, M., Lima-Engelmann, K. & Schneider, M. A comparison of spherical and cylindrical microparticles composed of nanoparticles for pulmonary application. Aerosol Sci. Technol. 53, 53–62 (2019).
    2. Chen, Y., Zhang, M. & Ren, F. A Role of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis. Molecules 24, 513 (2019).
    3. Zhu, C., Mahesula, S., Temple, S. & Kokovay, E. Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche. Stem Cell Rep. 12, 6–13 (2019).
    4. Ahn, J., Ryu, J., Song, G., Whang, M. & Kim, J. Network structure and enzymatic degradation of chitosan hydrogels determined by crosslinking methods. Carbohydr. Polym. 217, 160–167 (2019).
    5. Karvinen, J., Ihalainen, T. O., Calejo, M. T., Jönkkäri, I. & Kellomäki, M. Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studies. Mater. Sci. Eng. C 94, 1056–1066 (2019).
    6. Friedrich, M. et al. HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation. Mucosal Immunol. 12, 656 (2019).
    7. Grenier, J. et al. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta Biomater. (2019). doi:10.1016/j.actbio.2019.05.070
    8. Rincel, M. et al. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (Berl.) (2019). doi:10.1007/s00213-019-05252-w
    9. Navarro, J., Swayambunathan, J., Lerman, M., Santoro, M. & Fisher, J. P. Development of keratin-based membranes for potential use in skin repair. Acta Biomater. 83, 177–188 (2019).

2018

    1. das Graças C de Souza, M., Cyrino, F. Z., de Carvalho, J. J., Blanc-Guillemaud, V. & Bouskela, E. Protective Effects of Micronized Purified Flavonoid Fraction (MPFF) on a Novel Experimental Model of Chronic Venous Hypertension. Eur. J. Vasc. Endovasc. Surg. 55, 694–702 (2018).
    2. Andreev-Andrievskiy, A. A., Popova, A. S., Lagereva, E. A. & Vinogradova, O. L. Fluid shift versus body size: changes of hematological parameters and body fluid volume in hindlimb-unloaded mice, rats and rabbits. J. Exp. Biol. 221, (2018).
    3. Krug, S. M. et al. Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunol. 11, 345–356 (2018).
    4. Sureda, E. A., Prykhodko, O. & Weström, B. Early effects on the intestinal barrier and pancreatic function after enteral stimulation with protease or kidney bean lectin in neonatal rats. Br. J. Nutr. 119, 992–1002 (2018).
    5. Genser, L. et al. Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes. J. Pathol. 246, 217–230 (2018).
    6. Ahn, J., Ryu, J., Song, K. & Kim, J. Effects of Crosslinking Methods on Network Structure and Enzymatic Degradation of Methacrylate-Functionalized Chitosan Hydrogel. (2018). doi:10.26434/chemrxiv.7447490.v1
    7. Bücker, R. et al. Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol. 11, 474–485 (2018).
    8. Rincel, M. et al. Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats. Brain Struct. Funct. 223, 883–895 (2018).
    9. Gustafsson, S. et al. Blood-brain barrier integrity in a mouse model of Alzheimer’s disease with or without acute 3D6 immunotherapy. Neuropharmacology 143, 1–9 (2018).
    10. Seitz, R. et al. Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature. Invest. Ophthalmol. Vis. Sci. 59, 2240–2251 (2018).
    11. Zhang, K. et al. Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo. PLOS Pathog. 14, e1006925 (2018).
    12. Hübner, K. et al. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat. Commun. 9, 4860 (2018).

2017

    1. Collett, J. A. et al. Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys. J. Am. Soc. Nephrol. 28, 2081–2092 (2017).
    2. Van Skike, C. E. et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. Am. J. Physiol.-Heart Circ. Physiol. 314, H693–H703 (2017).
    3. Dong, X. et al. Formulation and Drug Loading Features of Nano-Erythrocytes. Nanoscale Res. Lett. 12, 202 (2017).
    4. Nultsch, K. & Germershaus, O. Silk fibroin degumming affects scaffold structure and release of macromolecular drugs. Eur. J. Pharm. Sci. 106, 254–261 (2017).
    5. Cording, J. et al. Trictide, a tricellulin-derived peptide to overcome cellular barriers. Ann. N. Y. Acad. Sci. 1405, 89–101 (2017).
    6. Ilatovskaya, D. V., Palygin, O., Levchenko, V., Endres, B. T. & Staruschenko, A. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci. Rep. 7, 299 (2017).
    7. Verhaegh, R., Petrat, F., Brencher, L., Kirsch, M. & de Groot, H. Autodigestion by migrated trypsin is a major factor in small intestinal ischemia-reperfusion injury. J. Surg. Res. 219, 266–278 (2017).
    8. B. Guerzoni, L. P. et al. Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules. Biomater. Sci. 5, 1549–1557 (2017).
    9. Li, B. et al. Development of Polymer Microcapsules Functionalized with Fucoidan to Target P-Selectin Overexpressed in Cardiovascular Diseases. Adv. Healthc. Mater. 6, 1601200 (2017).
    10. Epple, H.-J. et al. Architectural and functional alterations of the small intestinal mucosa in classical Whipple’s disease. Mucosal Immunol. 10, 1542–1552 (2017).
    11. Schuetz, A., Radusheva, V., Krug, S. M. & Heinemann, U. Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Ann. N. Y. Acad. Sci. 1405, 147–159 (2017).
    12. Endres, B. T. et al. Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. Am. J. Physiol.-Ren. Physiol. 313, F163–F173 (2017).
    13. Singh, P. et al. Neuropeptide Y regulates a vascular gateway for hematopoietic stem and progenitor cells. J. Clin. Invest. 127, 4527–4540 (2017).
    14. Bulant, C. A., Blanco, P. J., Müller, L. O., Scharfstein, J. & Svensjö, E. Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster. Microvasc. Res. 112, 53–64 (2017).
    15. Schlecht, A. et al. Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization. Am. J. Pathol. 187, 2570–2589 (2017).
    16. Lai De-Wei et al. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Circ. Res. 121, e37–e52 (2017).
    17. Nascimento, C. R. et al. Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease. Front. Immunol. 8, (2017).

2016

    1. Larrañeta, E. et al. A facile system to evaluate in vitro drug release from dissolving microneedle arrays. Int. J. Pharm. 497, 62–69 (2016).
    2. Dolowschiak, T. et al. IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection. Cell Host Microbe 20, 238–249 (2016).
    3. Brauer, R. et al. MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol. 9, 974–985 (2016).
    4. Thakur, R. R. S. et al. Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv. Transl. Res. 6, 800–815 (2016).
    5. Pirozzi, C. et al. Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. J. Nutr. Biochem. 30, 108–115 (2016).
    6. Soto, A. M. et al. Optical Projection Tomography Technique for Image Texture and Mass Transport Studies in Hydrogels Based on Gellan Gum. Langmuir 32, 5173–5182 (2016).
    7. Lee, S. et al. Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Sci. Rep. 6, 26923 (2016).
    8. Misiorek, J. O. et al. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 37, 777–786 (2016).

2015

    1. Huang, H. et al. Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition. Diabetes 64, 200–212 (2015).
    2. Davis, M. J. et al. Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence. J. Immunol. 194, 2219–2231 (2015).
    3. Braunger, B. M. et al. Deletion of Ocular Transforming Growth Factor β Signaling Mimics Essential Characteristics of Diabetic Retinopathy. Am. J. Pathol. 185, 1749–1768 (2015).
    4. Voiniciuc, C. et al. MUCILAGE-RELATED10 Produces Galactoglucomannan That Maintains Pectin and Cellulose Architecture in Arabidopsis Seed Mucilage. Plant Physiol. 169, 403–420 (2015).
    5. Sand, E. et al. Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum. BMC Res. Notes 8, 824 (2015).
    6. Laudien, J. et al. Perfluorodecalin-Filled Poly(n-butyl-cyanoacrylate) Nanocapsules as Potential Artificial Oxygen Carriers: Preclinical Safety and Biocompatibility. (2015). doi:info:doi/10.1166/jnn.2015.10044
    7. Gouyer, V. et al. Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier. Sci. Rep. 5, 9577 (2015).
    8. Dünnhaupt, S. et al. Thiolated nanocarriers for oral delivery of hydrophilic macromolecular drugs. Carbohydr. Polym. 117, 577–584 (2015).
    9. Chen, L., An, H. Z. & Doyle, P. S. Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates. Langmuir 31, 9228–9235 (2015).

SELECTED OLDER PUBLICATIONS

  1. Boa, B. C. S. et al. Chronic Aerobic Exercise Associated to Dietary Modification Improve Endothelial Function and eNOS Expression in High Fat Fed Hamsters. PLOS ONE 9, e102554 (2014).
  2. Sommer, J. et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. Int. J. Mol. Med. 34, 651–660 (2014).
  3. Bojko, A., Andreatta, G., Montagne, F., Renaud, P. & Pugin, R. Fabrication of thermo-responsive nano-valve by grafting-to in melt of poly(N-isopropylacrylamide) onto nanoporous silicon nitride membranes. J. Membr. Sci. 468, 118–125 (2014).
  4. Silva, J. V. C., Peixoto, P. D. S., Lortal, S. & Floury, J. Transport phenomena in a model cheese: The influence of the charge and shape of solutes on diffusion. J. Dairy Sci. 96, 6186–6198 (2013).
  5. Svensjö, E. et al. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1–CXCR1/2-pathway. Microvasc. Res. 83, 185–193 (2012).
  6. Chalaris, A. et al. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med. 207, 1617–1624 (2010).
  7. Monteiro, A. C. et al. Kinin Danger Signals Proteolytically Released by Gingipain Induce Fimbriae-Specific IFN-γ- and IL-17-Producing T Cells in Mice Infected Intramucosally with Porphyromonas gingivalis. J. Immunol. 183, 3700–3711 (2009).
  8. Asgeirsson, D., Venturoli, D., Fries, E., Rippe, B. & Rippe, C. Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation. Acta Physiol. 191, 237–246 (2007).
  9. Delius, S. et al. Transgastric in vivo histology in the peritoneal cavity using miniprobe-based confocal fluorescence microscopy in an acute porcine model. Endoscopy 39, 407–411 (2007).
  10. Mulherkar, P. & van Reis, R. Flex test: a fluorescent dextran test for UF membrane characterization. J. Membr. Sci. 236, 171–182 (2004).

Products


FITC-dextran 4 (FD4)

FITC-dextran 4 (FD4)

Price:
677 SEK
Select weight:
More information
FITC-dextran 10 (FD10)

FITC-dextran 10 (FD10)

Price:
660 SEK
Select weight:
More information
FITC-dextran 20 (FD20)

FITC-dextran 20 (FD20)

Price:
660 SEK
Select weight:
More information
FITC-dextran 40 (FD40)

FITC-dextran 40 (FD40)

Price:
660 SEK
Select weight:
More information
FITC-dextran 70 (FD70)

FITC-dextran 70 (FD70)

Price:
660 SEK
Select weight:
More information
FITC-dextran 110 (FD110)

FITC-dextran 110 (FD110)

Price:
1240 SEK
Select weight:
More information
FITC-dextran 150 (FD150)

FITC-dextran 150 (FD150)

Price:
660 SEK
Select weight:
More information
FITC-dextran 500 (FD500)

FITC-dextran 500 (FD500)

Price:
660 SEK
Select weight:
More information
FITC-dextran 2000 (FD2000)

FITC-dextran 2000 (FD2000)

Price:
660 SEK
Select weight:
More information