FITC-dextrans have now been used for 25 years for studying microcirculation or membrane permeability.
FITC dextrans are prepared from special dextran fractions by coupling to fluoresceinyl isothiocyanate (5-isomer). The number of FITC substituents ranges from 0.002-0.008 per glucose unit. At these low degrees of substitution, the charge contribution from the carboxyl group on the fluoresceinyl moiety is negligible. All batches are checked for molecular weight, loss on drying and free FITC.
If you need larger quantities please contact us for a bulk quotation.
For a presentation of intravital studies using fluorescent dextrans intravital_studies.pdf.