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High sulfated Dextran sulfates - for research and development

Dextran sulfates are produced by sulfation of selected dextran fractions. We now supply two series of dextran sulfates; one series with high levels of sulfation (16-20% sulfur) and another series with lower sulfation (8-13% sulfur).

Please observe that the products are characterised by the approximate molecular weights of the final products. The molecular weights are determined by Size Exclusion Chromatography using dextran calibration. The same dextran fraction is used to make the high and the low sulfated products but this results in somewhat lower mean molecular weight values for the lower sulfated products. 

Specifications for each product are available on request. 

Dextran sulfates act as potent polyanions and offer many interesting pharmacological and biophysical properties. Some examples of the areas of application are given below:

  • cosmetics formulations 
  • stabilisation of sensitive biopolymers during processing or formulation 
  • enzyme activation or inhibition 
  • anti-viral preparations 
  • acceleration of hydridisation 

If you need larger quantities please contact us for a bulk quotation.

References

Have you cited this product in a publication? Let us know so we can reference it.

    1. Möhwald, M. et al. Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages. Adv Healthc Mater 6, (2017).
    2. Dijk, M. et al. How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure 24, 2182–2189 (2016).
    3. Shahraz, A. et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Scientific Reports 5, 16800 (2015).
    4. Svensjö, E., Nogueira de Almeida, L., Vellasco, L., Juliano, L. & Scharfstein, J. Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptors. Mediators of Inflammation (2014). doi:10.1155/2014/143450
    5. Parraga, J. E., Zorzi, G. K., Diebold, Y., Seijo, B. & Sanchez, A. Nanoparticles based on naturally-occurring biopolymers as versatile delivery platforms for delicate bioactive molecules: An application for ocular gene silencing. International Journal of Pharmaceutics 477, 12–20 (2014).
    6. Svensjö, E. et al. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1–CXCR1/2-pathway. Microvascular Research 83, 185–193 (2012).
    7. Russo, L. M. et al. Renal Processing of Albumin in Diabetes and Hypertension in Rats. AJN 23, 61–70 (2003).
    8. Landauer, K. et al. Influence of Carboxymethyl Dextran and Ferric Citrate on the Adhesion of CHO Cells on Microcarriers. Biotechnology Progress 19, 21–29 (2003).
    9. Hugerth, A. M. Micropolarity and Microviscosity of Amitriptyline and Dextran Sulfate/Carrageenan‐Amitriptyline Systems: The Nature of Polyelectrolyte–Drug Complexes. Journal of Pharmaceutical Sciences 90, 1665–1677 (2001).
    10. Persson, B., Hugerth, A., Caram-Lelham, N. & Sundelöf, L.-O. Dextran Sulfate−Amphiphile Interaction; Effect of Polyelectrolyte Charge Density and Amphiphile Hydrophobicity. Langmuir 16, 313–317 (2000).
    11. Hugerth, A. & Sundelöf, L.-O. Effect of Polyelectrolyte Counterion Specificity on Dextran Sulfate−Amphiphile Interaction in Water and Aqueous/Organic Solvent Mixtures. Langmuir 16, 4940–4945 (2000).
    12. Burne, M. J. et al. Anomalous decrease in dextran sulfate clearance in the diabetic rat kidney. American Journal of Physiology-Renal Physiology 274, F700–F708 (1998).
    13. Caram‐Lelham, N., Hed, F. & Sundelöf, L.-O. Adsorption of charged amphiphiles to oppositely charged polysaccharides—A study of the influence of polysaccharide structure and hydrophobicity of the amphiphile molecule. Biopolymers 41, 765–772 (1997).
    14. Vyas, S. V., Burne, M. J., Pratt, L. M. & Comper, W. D. Glomerular Processing of Dextran Sulfate during Transcapillary Transport. Archives of Biochemistry and Biophysics 332, 205–212 (1996).
    15. Wells, X. E. & Dawes, J. Role of the Liver and Kidney in the Desulphation of Heparin in vivo. Thromb Haemost 74, 667–672 (1995).
    16. Vyas, S. V., Parker, J.-A. & Comper, W. D. Uptake of dextran sulphate by glomerular intracellular vesicles during kidney ultrafiltration. Kidney International 47, 945–950 (1995).

Products


Dextran sulfate 5 (DB004)

Dextran sulfate 5 (DB004)

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938 SEK
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Dextran sulfate 10 (DB008)

Dextran sulfate 10 (DB008)

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938 SEK
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Dextran sulfate 20 (DB012)

Dextran sulfate 20 (DB012)

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938 SEK
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Dextran sulfate 100 (DB016)

Dextran sulfate 100 (DB016)

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938 SEK
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Dextran sulfate 500 (DB050)

Dextran sulfate 500 (DB050)

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938 SEK
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Dextran sulfate 2000 (DB054)

Dextran sulfate 2000 (DB054)

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938 SEK
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